The University of Oklahoma is expected to play the first-ranked Penn State Nittany Lions in the 2021 Cotton Bowl in Arlington, Texas.
The game is set to take place on Sept. 17, 2021.
The Big 12 Conference announced its 2019 season schedule on Monday.
The conference also announced that the Big 12 Championship Game will be played in 2021, the first time since 2010 that the conference has hosted a title game.
The conference is scheduled to play 12 non-conference games, with nine of those games being against Power 5 opponents, including two against teams in the Mountain West.
The league is also set to host five home-and-home series against FBS opponents.
The Oklahoma-Penn State game is the third time the Big Ten has hosted an annual meeting between the two schools in the past two years.
The last meeting between these schools was in 2010, when the Sooners won 41-14 at home.